Digoxin , >96.0%(HPLC) , 20830-75-5
Synonym(s):
12β-Hydroxydigitoxin;Digoxin
CAS NO.：20830-75-5
Empirical Formula: C41H64O14
Molecular Weight: 780.95
MDL number: MFCD00003674
EINECS: 244-068-1
PRODUCT Properties
| Melting point: | 248 °C |
| alpha | 25Hg +13.4 to 13.8° (c = 10 in pyridine) |
| Boiling point: | 661.93°C (rough estimate) |
| Density | 1.1110 (rough estimate) |
| refractive index | 12 ° (C=10, Pyridine) |
| Flash point: | 9℃ |
| storage temp. | Refrigerator |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | powder |
| pka | 13.50±0.70(Predicted) |
| color | White to Almost white |
| biological source | plant (Digitalis lanata) |
| Water Solubility | 46.08mg/L(room temperature) |
| Merck | 14,3167 |
| BRN | 77011 |
| BCS Class | 1 (LogP),
3 (CLogP) |
| Major Application | food and beverages forensics and toxicology veterinary |
| InChIKey | LTMHDMANZUZIPE-PUGKRICDSA-N |
| LogP | 1.260 |
| CAS DataBase Reference | 20830-75-5 |
| IARC | 2B (Vol. 108) 2016 |
| EPA Substance Registry System | Digoxin (20830-75-5) |
Description and Uses
Digoxin, 3β,14β-dihydroxy-5β-card-20(22)-enolide-3-rigitoxide, is also a glycoside isolated from various types of foxgloves. It differs from digitoxin in that it has an additional hydroxyl group at C16 of the steroid skeleton. It is extracted form the leaves of Digitalis lanta, Digitalis orientalis, or Scrophulariaceae.
Digoxin exhibits strong systolic action and slows heart rate. It is removed from the organism faster than digitoxin. It is used from chronic cardiac insufficiency in decompensated valvular disease of the heart, myocardium overload in arterial hypertension, tachycardia, ventricular fibrillation, and other analogous situations.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300-H331-H373 |
| Precautionary statements | P260-P264-P270-P301+P310-P304+P340+P311-P314 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T,T+,F |
| Risk Statements | 25-26/27/28-23/25-39/23/24/25-23/24/25-11-28-26 |
| Safety Statements | 22-36/37/39-45-36/37-16-28A |
| RIDADR | UN 3462 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | IH6125000 |
| F | 3-10 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29389090 |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| Hazard Classifications | Acute Tox. 2 Oral Acute Tox. 3 Inhalation STOT RE 2 |
| Hazardous Substances Data | 20830-75-5(Hazardous Substances Data) |
| Toxicity | cat,LD50,oral,200ug/kg (0.2mg/kg),Archives Internationales de Pharmacodynamie et de Therapie. Vol. 159, Pg. 1, 1966. |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Max Inner Pack (1g or 1ml) and Max Outer Pack (500g or 500ml) |
