PurvalanolA , ≥98% , 212844-53-6

Synonym(s):
2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine;2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine;NG-60;Purvalanol A - CAS 212844-53-6 - Calbiochem

CAS NO.：212844-53-6

Empirical Formula: C19H25ClN6O

Molecular Weight: 388.89

MDL number: MFCD02179211

PRODUCT Properties

• Boiling point: 590.5±60.0 °C(Predicted)
• Density: 1.33±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: methylene chloride: 50 mg/mL, clear, colorless
• form: powder
• pka: 14.51±0.10(Predicted)
• color: off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1?Reversibly arrests synchronized cells in G1 and G2 phase.2?Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3?Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4?In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5?Cell permeable.

Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P271-P261-P280
• WGK Germany: 3
• HS Code: 2933599590