Boc-Pro-OH , 99% , 15761-39-4

Synonym(s):
N-(tert-Butoxycarbonyl)-L-proline;Boc-L-proline;Boc-Pro-OH;N-α-t.-Boc-L-proline

CAS NO.：15761-39-4

Empirical Formula: C10H17NO4

Molecular Weight: 215.25

MDL number: MFCD00037324

EINECS: 239-848-3

PRODUCT Properties

• Melting point: 133-135 °C(lit.)
• alpha: -60.5 º (c=1, HAc)
• Boiling point: 355.52°C (rough estimate)
• Density: 1.1835 (rough estimate)
• refractive index: -60 ° (C=2, AcOH)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: Soluble in acetic acid.
• pka: 4.01±0.20(Predicted)
• form: Crystals or Crystalline Powder
• color: White
• optical activity: [α]20/D 61±2°, c = 2% in acetic acid
• BRN: 15828
• Major Application: peptide synthesis
• InChI: 1S/C10H17NO4/c1-10(2,3)15-9(14)11-6-4-5-7(11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
• InChIKey: ZQEBQGAAWMOMAI-ZETCQYMHSA-N
• SMILES: CC(C)(C)OC(=O)N1CCC[C@H]1C(O)=O
• CAS DataBase Reference: 15761-39-4(CAS DataBase Reference)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- (15761-39-4)

Description and Uses

N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• TSCA: TSCA listed
• HS Code: 2933 99 80
• HazardClass: IRRITANT
• Storage Class: 11 - Combustible Solids