1H-Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate , 98% , 128625-52-5

Synonym(s):
Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate;PyBOP

CAS NO.：128625-52-5

Empirical Formula: C18H28F6N6OP2

Molecular Weight: 520.39

MDL number: MFCD00077411

EINECS: 603-290-2

PRODUCT Properties

• Melting point: 154-156 °C (dec.)(lit.)
• Density: 1.438 at 20℃
• vapor pressure: 0-0Pa at 20-50℃
• storage temp.: 2-8°C
• solubility: methanol: 25 mg/mL, clear
• form: Fine Crystalline Powder
• color: White to off-white
• Sensitive: Moisture Sensitive
• BRN: 3584612
• InChI: InChI=1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1
• InChIKey: BYCLGHOAELJLOF-UHFFFAOYSA-M
• SMILES: [P+](ON1N=NC2C=CC=CC1=2)(N1CCCC1)(N1CCCC1)N1CCCC1.[P-](F)(F)(F)(F)(F)F
• LogP: -0.3 at 26℃ and pH3.5-3.7
• CAS DataBase Reference: 128625-52-5(CAS DataBase Reference)

Description and Uses

One of the most convenient coupling reagents for peptide synthesis without carcinogenic by-products. It replaces BOP reagent. This is especially suitable for solid-phase peptide synthesis, avoids racemization.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H302-H317-H410
• Precautionary statements: P261-P264-P273-P280-P301+P312-P302+P352
• Hazard Codes: Xi
• Risk Statements: 37/38-44-36/37/38
• Safety Statements: 26-36-24/25-37/39
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• F: 8-10-21
• Hazard Note: Irritant
• HS Code: 29339980