Azacyclonol , ≥99% , 115-46-8

Synonym(s):
Azacyclonol;Diphenyl-4-piperidinemethanol

CAS NO.：115-46-8

Empirical Formula: C18H21NO

Molecular Weight: 267.37

MDL number: MFCD00066980

EINECS: 204-092-5

PRODUCT Properties

• Melting point: 160-163 °C
• Boiling point: 410.55°C (rough estimate)
• Density: 1.0449 (rough estimate)
• vapor pressure: 0Pa at 25℃
• refractive index: 1.5100 (estimate)
• storage temp.: Store below +30°C.
• solubility: Chloroform, Methanol (Slightly, Sonicated)
• pka: 13.32±0.29(Predicted)
• form: Solid
• color: White to light beige
• InChI: InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
• InChIKey: ZMISODWVFHHWNR-UHFFFAOYSA-N
• SMILES: C(O)(C1CCNCC1)(C1=CC=CC=C1)C1=CC=CC=C1
• CAS DataBase Reference: 115-46-8(CAS DataBase Reference)
• NIST Chemistry Reference: Azacyclonol(115-46-8)

Description and Uses

alpha,alpha-Diphenyl-4-piperidinomethanol is an important organic synthetic substance for the synthesis of diphenyl-4-piperidinomethanol. It is also used as a pharmaceutical intermediate in the preparation of terfenadine and Fexofenadine hydrochloride.

α-(4-Piperidyl)benzhydrol is a key intermediate in the synthesis of Fexofenadine (F322490). Fexofenadine EP Impurity E.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H319
• Precautionary statements: P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: WGK 3 highly water endangering
• RTECS: TN0470000
• HS Code: 29333999
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Eye Irrit. 2