Rolipram , ≥97% , 61413-54-5

Synonym(s):
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone;Rolipram - CAS 61413-54-5 - Calbiochem;ZK 62711

CAS NO.：61413-54-5

Empirical Formula: C16H21NO3

Molecular Weight: 275.34

MDL number: MFCD00270906

EINECS: 262-771-1

PRODUCT Properties

• Melting point: 127-133 °C
• Boiling point: 418.29°C (rough estimate)
• Density: 1.0677 (rough estimate)
• refractive index: 1.5500 (estimate)
• storage temp.: Sealed in dry,Store in freezer, under -20°C
• solubility: H₂O: 0.2 mg/mL
• form: solid
• pka: 16.02±0.40(Predicted)
• color: white to off-white
• biological source: synthetic (organic)
• Water Solubility: H2O: 0.2mg/mL; ethanol: 7mg/mL; DMSO: 7.3mg/mL
• Merck: 14,8251
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChI: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
• InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
• SMILES: O(C1CCCC1)C1C=C(C2CC(NC2)=O)C=CC=1OC

Description and Uses

Rolipram (61413-54-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 1 μM. Displays beneficial effects in neurodegenerative diseases. Rolipram also displays anti-inflammatory activity and synergizes with forskolin (cat.# 10-2073). Cell permeable.

(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38-11
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: UY5749237
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29337900
• Toxicity: LD50 oral in mouse: > 300mg/kg