(2<i>S</i>,4<i>R</i>)-1-(<i>tert</i>-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid , >96.0%(T) , 203866-14-2

CAS NO.：203866-14-2

Empirical Formula: C10H16FNO4

Molecular Weight: 233.24

MDL number: MFCD06796085

PRODUCT Properties

• Melting point: 115-119°C
• Boiling point: 346.0±42.0 °C(Predicted)
• Density: 1.24±0.1 g/cm3(Predicted)
• refractive index: -69 ° (C=1, MeOH)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: soluble in Methanol
• form: powder to crystal
• pka: 3.53±0.40(Predicted)
• color: White to Almost white
• optical activity: [α]22/D -65.0±5°, c = 1 in chloroform
• InChI: InChI=1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7+/m1/s1
• InChIKey: YGWZXQOYEBWUTH-RQJHMYQMSA-N
• SMILES: N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(O)=O
• CAS DataBase Reference: 203866-14-2(CAS DataBase Reference)

Description and Uses

N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29339900