MRE-269(ACT-333679) , 10mMinDMSO , 475085-57-5

CAS NO.：475085-57-5

Empirical Formula: C25H29N3O3

Molecular Weight: 419.52

MDL number: MFCD11976884

PRODUCT Properties

• Melting point: 116 - 118°C
• Boiling point: 602.1±55.0 °C(Predicted)
• Density: 1.160
• storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 3.51±0.10(Predicted)
• form: Solid
• color: Off-White to Light Yellow
• InChIKey: OJQMKCBWYCWFPU-UHFFFAOYSA-N
• SMILES: C(O)(=O)COCCCCN(C1=NC(C2=CC=CC=C2)=C(C2=CC=CC=C2)N=C1)C(C)C

Description and Uses

Prostacyclin (PGI₂) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a K_i value of 20 nM. In contrast to PGI₂, which has a half-life of 30 seconds to a few minutes in vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI₂ analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP₃ receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP₃-mediated vasoconstriction.

MRE-269 an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269 is used for the treatment of pulmonary arterial hypertension. MRE-269 is an active metabolite of Selexipag (S253150).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338