Trifluoroacetamide , 97% , 354-38-1

Synonym(s):
2,2,2-Trifluoroacetamide

CAS NO.：354-38-1

Empirical Formula: C2H2F3NO

Molecular Weight: 113.04

MDL number: MFCD00008008

EINECS: 206-559-9

PRODUCT Properties

• Melting point: 65-70 °C (lit.)
• Boiling point: 162.5 °C (lit.)
• Density: 1.4176 (estimate)
• bulk density: 960kg/m3
• Flash point: 162-164°C
• storage temp.: Store below +30°C.
• solubility: 460 g/L (20°C)
• form: Crystalline Powder or Crystals
• pka: 12.33±0.50(Predicted)
• color: White to pale yellow or beige
• PH: 3.6 (460g/l, H2O, 23℃)
• Water Solubility: 460 g/L (20 ºC)
• BRN: 1753625
• InChI: 1S/C2H2F3NO/c3-2(4,5)1(6)7/h(H2,6,7)
• InChIKey: NRKYWOKHZRQRJR-UHFFFAOYSA-N
• SMILES: NC(=O)C(F)(F)F
• LogP: 0.725 at 23℃ and pH4.83
• Dissociation constant: 0 at 23℃
• CAS DataBase Reference: 354-38-1(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-(354-38-1)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro- (354-38-1)

Description and Uses

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
• target organs: Respiratory system
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• RIDADR: 1759
• WGK Germany: 3
• Hazard Note: Harmful/Irritant
• TSCA: TSCA listed
• HazardClass: 8
• PackingGroup: III
• HS Code: 29241900
• Storage Class: 13 - Non Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Eye Irrit. 2; Skin Irrit. 2; STOT SE 3