Withaferin A , Analysis standard , 5119-48-2
Synonym(s):
4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone;5,6-Epoxy-4,27-dihydroxy-1-oxowitha-2,24-dienolide;Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem;Withaferine;Withaferine A
CAS NO.：5119-48-2
Empirical Formula: C28H38O6
Molecular Weight: 470.6
MDL number: MFCD10687098
EINECS: 999-999-2
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB2479.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 252-253℃ |
| alpha | D28 +125° (c = 1.30 in CHCl3) |
| Boiling point: | 680.7±55.0 °C(Predicted) |
| Density | 1.28 |
| Flash point: | 226℃ |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in DMSO (up to 20 mg/ml) |
| pka | 13.49±0.70(Predicted) |
| form | White solid |
| color | White |
| biological source | plant (Withania somnifera) |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Major Application | food and beverages |
| InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
| SMILES | C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C |
Description and Uses
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro(IC50= 12 nM) andin vivo.1Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2Covalently binds to the intermediate filament protein, vimentin3inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis inin vivomodels.5
Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| Hazard Codes | T |
| WGK Germany | 3 |
| RTECS | KE7288500 |
| HS Code | 29322090 |
| Storage Class | 11 - Combustible Solids |
