ZM 336372 , ≥98% , 208260-29-1

Synonym(s):
3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide;N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide;ZM 336372 - CAS 208260-29-1 - Calbiochem

CAS NO.：208260-29-1

Empirical Formula: C23H23N3O3

Molecular Weight: 389.45

MDL number: MFCD02683971

PRODUCT Properties

• Boiling point: 484.4±45.0 °C(Predicted)
• Density: 1.298
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: DMSO: >5mg/mL (warmed)
• pka: 8.31±0.15(Predicted)
• form: powder
• color: white to beige
• Sensitive: Light Sensitive
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
• InChI: 1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
• InChIKey: PYEFPDQFAZNXLI-UHFFFAOYSA-N
• SMILES: N(C)(C)c1cc(ccc1)C(=O)Nc2cc(c(cc2)C)NC(=O)c3ccc(cc3)O

Description and Uses

The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro (IC₅₀ = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells. Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.

It is small molecule tyrosine kinase modulator. ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317-H413
• Precautionary statements: P261-P272-P273-P280-P302+P352-P333+P313
• WGK Germany: 3
• HS Code: 2924297099
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Aquatic Chronic 4; Skin Sens. 1B