tert-Butyl (3s)-3-(4-bromophenyl)-piperidine-1-carboxylate , 98% , 1476776-55-2

CAS NO.：1476776-55-2

Empirical Formula: C16H22BrNO2

Molecular Weight: 340.26

MDL number: MFCD27987933

EINECS: 1533716-785-6

PRODUCT Properties

• Boiling point: 398.5±42.0 °C(Predicted)
• Density: 1.283±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• pka: -1.84±0.40(Predicted)
• form: solid
• color: Off-white
• optical activity: -59.3°(C=0.01g/ mI, CHCL3 , 20°C, 589nm)
• InChI: InChI=1S/C16H22BrNO2/c1-16(2,3)20-15(19)18-10-4-5-13(11-18)12-6-8-14(17)9-7-12/h6-9,13H,4-5,10-11H2,1-3H3/t13-/m1/s1
• InChIKey: WRSHWNCUNYWQBB-CYBMUJFWSA-N
• SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H](C2=CC=C(Br)C=C2)C1

Description and Uses

tert-?Butyl (S)?-?3-?(4-?Bromophenyl)?piperidine-?1-?carboxylate is an intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• HS Code: 2933399990