M4493235
Niraparibhydrochloride , 99% , 1038915-64-8
CAS NO.：1038915-64-8
Empirical Formula: C19H20N4O
Molecular Weight: 320.388
MDL number: MFCD20502397
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB246.40 | In Stock |
|
| 50mg | RMB691.20 | In Stock |
|
| 100mg | RMB1270.40 | In Stock |
|
| 500mg | RMB4822.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 144 °C |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to light yellow |
| InChI | InChI=1/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/s3 |
| InChIKey | PCHKPVIQAHNQLW-WDHUHKLTNA-N |
| SMILES | N1=C2C(C=CC=C2C(N)=O)=CN1C1=CC=C([C@@H]2CCCNC2)C=C1 |&1:16,r| |
Description and Uses
Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405 |
