M4025335
MK-4827tosylate , 99% , 1038915-73-9
CAS NO.：1038915-73-9
Empirical Formula: C26H28N4O4S
Molecular Weight: 492.59
MDL number: MFCD28167748
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB522.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >142oC (dec.) |
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Yellow |
| InChIKey | LCPFHXWLJMNKNC-XOIICWPPNA-N |
| SMILES | S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r| |
Description and Uses
Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.
Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
