2,5-Dioxopyrrolidin-1-yl19-(2,5-dioxo-2H-pyrrol-1(5H)-yl)-17-oxo-4,7,10,13-tetraoxa-16-azanonadecan-1-oate , 99% , 756525-99-2

Synonym(s):
N-[15-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-2,5-dihydro-2,5-dioxo-1H-pyrrole-1-propanamide;monodisperse Mal-PEG4-NHS-ester

CAS NO.：756525-99-2

Empirical Formula: C22H31N3O11

Molecular Weight: 513.49

MDL number: MFCD11041113

EINECS: 201-258-5

PRODUCT Properties

• Density: 1.36±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: Soluble in DMSO
• form: Solid
• pka: 15.01±0.46(Predicted)
• color: White to off-white
• InChI: InChI=1S/C22H31N3O11/c26-17(5-8-24-18(27)1-2-19(24)28)23-7-10-33-12-14-35-16-15-34-13-11-32-9-6-22(31)36-25-20(29)3-4-21(25)30/h1-2H,3-16H2,(H,23,26)
• InChIKey: XSRYGQJQNPJNKZ-UHFFFAOYSA-N
• SMILES: C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O

Description and Uses

Mal-amido-PEG4-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Maleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• HS Code: 2928009090