BD4946841
XL388 , 98% , 1251156-08-7
Synonym(s):
[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]-methanone;XL-388
CAS NO.：1251156-08-7
Empirical Formula: C23H22FN3O4S
Molecular Weight: 455.5
MDL number: MFCD24386875
| Pack Size | Price | Stock | Quantity |
| 25mg | RMB603.20 | In Stock |
|
| 50mg | RMB1024.80 | In Stock |
|
| 100mg | RMB1741.60 | In Stock |
|
| 250mg | RMB2960.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >188oC (dec.) |
| Boiling point: | 738.6±60.0 °C(Predicted) |
| Density | 1.354±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 6.22±0.13(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| Stability: | Hygroscopic |
| InChI | 1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) |
| InChIKey | LNFBAYSBVQBKFR-UHFFFAOYSA-N |
| SMILES | Fc1c(ccc(c1C)C(=O)N2CCOc3c(cc(cc3)c4c[nH][c](cc4)=N)C2)[S](=O)(=O)C |
Description and Uses
XL388 is a highly potent, orally bioavailable, selective, ATP-competitive mammalian target of rapamycin (mTOR) inhibitor. XL388 has shown significant and dose-dependent antitumor activity in athymic nude mice implanted with human tumor xenografts.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
