Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate , 97% , 160844-75-7

CAS NO.：160844-75-7

Empirical Formula: C18H20N2O3S

Molecular Weight: 344.43

MDL number: MFCD09833701

EINECS: 927-913-5

PRODUCT Properties

• Melting point: 176 °C
• Boiling point: 497.1±55.0 °C(Predicted)
• Density: 1.22
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
• form: Solid
• pka: 1.02±0.10(Predicted)
• color: White to Off-White
• InChI: InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
• InChIKey: OGAZOYHQFBSRMC-UHFFFAOYSA-N
• SMILES: S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1
• CAS DataBase Reference: 160844-75-7(CAS DataBase Reference)

Description and Uses

Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
• HS Code: 2934.10.2000
• REACH Registrations: Active