LN3283049
Dofequidarfumarate , ≥98% , 158681-49-3
Synonym(s):
4-(Diphenylacetyl)-a-[(5-quinolinyloxy)methyl]-1-Piperazineethanol (E)-2-butenedioate fumarate (1:1.5);MS-209 fumarate
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1048.00 | In Stock |
|
| 10mg | RMB1676.00 | In Stock |
|
| 50mg | RMB5508.00 | In Stock |
|
| 100mg | RMB8520.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | -20°C |
| solubility | DMSO: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
Description and Uses
Dofequidar (MS-209) sesquifumarate is an orally active quinoline compoundthat blocks P-glycoprotein (P-gp) and multidrug resistance-associated protein-1 (MDR-1). Dofequidar sesquifumarate has highly potent reversing effect on multidrug-resistant tumor cells. Dofequidar sesquifumarate competitively inhibits ABCB1/P-gp, ABCC1/MRP-1, blocks the efflux of chemotherapeutic agents, increases the drug concentration in cancer cells, and enhances the chemotherapeutic effect[1][2].
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H361-H412 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P201-P202-P281-P308+P313-P405-P501-P273-P501 |
| WGK Germany | 3 |
