ProstaglandinE2-1-glycerylester , ≥98% , 37497-47-5

CAS NO.：37497-47-5

Empirical Formula: C23H38O7

Molecular Weight: 426.54

MDL number: MFCD05863940

PRODUCT Properties

• solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 100 μg/ml

Description and Uses

2-Arachidonoyl glycerol (2-AG; ) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB₁ receptor.^1,2 Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H₂ (PGH₂) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.³ The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.⁴

Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+[1][2].

Safety

• Symbol(GHS): GHS02,GHS07,GHS08
• Signal word: Danger
• Hazard statements: H225-H319-H360
• Precautionary statements: P201-P202-P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P308+P313-P337+P313-P370+P378-P403+P235-P405-P501