M8066547
ProstaglandinH1(PGH1) , 98% , 52589-22-7
| Pack Size | Price | Stock | Quantity |
| 50μg | RMB2532.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 486.2±38.0 °C(Predicted) |
| Density | 1.113±0.06 g/cm3(Predicted) |
| Flash point: | -17 °C |
| storage temp. | −70°C |
| solubility | Ethanol: >100 mg/ml; PBS pH 7.2: >2 mg/ml |
| form | acetone solution |
| pka | 4.78±0.10(Predicted) |
Description and Uses
Prostaglandin H1 (PGH1) is the unstable precursor to all 1-series PGs and thromboxanes.1,2,3 It is produced from dihomo-γ-linolenic acid (DGLA; Item No. 90230) by COX-1 and COX-2. 4,2 PGH1 is an agonist of the PGD2 receptor CRTH2.5 It increases intracellular calcium levels in HEK293 cells expressing CRTH2 when used at a concentration of 3 µM and induces CRTH2 internalization at 1 µM, an effect that can be blocked by the CRTH2 antagonist TM30089 (CAY10471; Item No. 10006735). PGH1 is also a suicide inhibitor of platelet thromboxane synthase (Ki = 28 µM).6WARNING This product is not for human or veterinary use.
Safety
| Hazard Codes | F,Xi |
| Risk Statements | 11-36-66-67 |
| Safety Statements | 9-16-26 |
| RIDADR | UN 1090 3/PG 2 |
| WGK Germany | 1 |
