M9273134
A-966492 , 99% , 934162-61-5
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB544.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 605.5±65.0 °C(Predicted) |
| Density | 1.335 |
| storage temp. | Store at -20°C |
| solubility | ≥32.4 mg/mL in DMSO; ≥16.53 mg/mL in H2O with ultrasonic; ≥3.16 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 9.33±0.30(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C18H17FN4O/c19-13-9-10(14-5-2-8-21-14)6-7-11(13)18-22-15-4-1-3-12(17(20)24)16(15)23-18/h1,3-4,6-7,9,14,21H,2,5,8H2,(H2,20,24)(H,22,23)/t14-/m0/s1 |
| InChIKey | AHIVQGOUBLVTCB-AWEZNQCLSA-N |
| SMILES | C1(C2=CC=C([C@@H]3CCCN3)C=C2F)NC2=C(C(N)=O)C=CC=C2N=1 |
Description and Uses
A-966492 effectively inhibits PARP-1 with an EC50 of 1 nM and a Ki value of 1 nM. When it acts on PARP-2, the Ki value is 1.5 nM. It has excellent efficacy on PARP enzyme, especially on C41 cells. A-966492 significantly enhanced the effect of TMZ in a dose-dependent manner.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
