0.7umporesize,hydrophilicbinderlessglassfiber,124mmdiameter

Synonym(s):
1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate;Meridia;Reductil;Sibutramine hydrochloride monohydrate

CAS NO.：

Empirical Formula: C17H29Cl2NO

Molecular Weight: 334.32

MDL number: MFCD04039806

EINECS: 603-075-3

Update time: 2022-07-08

PRODUCT Properties

Melting point:	193-195.5°C
Flash point:	9℃
storage temp.	Room temp
solubility	DMSO: >30mg/mL
form	solid
color	white

Description and Uses

Sibutramine was introduced as Meridia in the US for the control of obesity, in conjunction with a reduced-calorie diet. Sibutramine can be prepared in four steps from 4-chlorobenzyl cyanide. Sibutramine acts as a serotonin and noradrenaline reuptake inhibitor ; in animal studies, it reduces energy intake by creating a satieted feeling and increases energy expenditure by enhancing thermogenesis. In a clinical study in obese patients treated with 10 or 15 mg of Sibutramine once-daily, meaningful weight loss was sustained for 12 months ; an additional study demonstrated a lack of abuse potential. An appreciable part of Sibutramine's effect would also be due to its 2N-mono and didesmethylmetabolites, which are very potent monoamine reuptake inhibitors themselves.

A serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure

Safety

Symbol(GHS)	GHS02,GHS06,GHS08
Signal word	Danger
Hazard statements	H225-H301+H311+H331-H370
Precautionary statements	P210-P260-P280-P301+P310-P311
Hazard Codes	Xi,T,F
Risk Statements	36/37/38-39/23/24/25-23/24/25-11
Safety Statements	22-24/25-36-26-45-36/37-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	3