Fmoc-β-azido-Ala-OH , ≥98.0%(HPLC) , 684270-46-0

Synonym(s):
(S)-3-Azido-2-(Fmoc-amino)propionic acid;Fmoc-3-azido-L-alanine

CAS NO.：684270-46-0

Empirical Formula: C18H16N4O4

Molecular Weight:

MDL number: MFCD11052919

PRODUCT Properties

• Melting point: >155 (dec.)
• storage temp.: 2-8°C
• solubility: DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White to Off-White
• optical activity: [α]/D -10.0±1.0°, c = 1 in DMF
• Major Application: peptide synthesis
• InChI: InChI=1/C18H16N4O4/c19-22-20-9-16(17(23)24)21-18(25)26-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15/h1-8,15-16H,9-10H2,(H,21,25)(H,23,24)/t16-/s3
• InChIKey: ZITYCUDVCWLHPG-QEIABERDNA-N
• SMILES: C(C1C2=CC=CC=C2C2=CC=CC=C12)OC(=O)N[C@H](C(=O)O)CN=[N+]=[N-] |&1:18,r|

Description and Uses

Fmoc-β-azido-Ala-OH chloride is a general N-terminal protected reagent used in the solid phase peptide synthesis. Azido group allows it to undergo copper-mediated click chemistry reactions.
It can be used in:

• Synthesis of α-N-acetylgalactosamine (α-GalNAc) linked antifreeze glycopeptides (AFGPs).
• Synthesis of stimuli-responsive multifunctional peptide gatekeepers for drug delivery applications.
• Synthesis of triazole-linked glycopeptides via Cu(I)-catalyzed 1,3-dipolar cycloaddition (CuAAC).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H335-H315
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HS Code: 2924297099
• Storage Class: 11 - Combustible Solids