Cytochalasin A from Drechslera dematioidea , 14110-64-6

CAS NO.：14110-64-6

Empirical Formula: C29H35NO5

Molecular Weight: 477.59

MDL number: MFCD00005935

EINECS: 237-964-9

PRODUCT Properties

• Melting point: 190-191 °C
• Boiling point: 725.1±60.0 °C(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: ethanol: 20 mg/mL, clear, colorless
• pka: 13.54±0.70(Predicted)
• form: Powder
• color: White
• Water Solubility: Soluble in DMF, DMSO, ethanol and acetone. Insoluble in water.
• Sensitive: Light Sensitive
• BRN: 949521
• InChIKey: ZMAODHOXRBLOQO-TZVKRXPSSA-N
• SMILES: C[C@@H]1CCCC(=O)\C=C\C(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O
• LogP: 1.849 (est)
• EPA Substance Registry System: Cytochalasin A (14110-64-6)

Description and Uses

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin A is an oxidized analog of cytochalasin B which uniquely inhibits HIV-1 protease (IC₅₀ = 3 μM). Cytochalasins A and B differ from other cytochalasins in being able to rapidly and reversibly inhibit glucose transport by competitively binding glucose transporters (K_i = 4.0 and 0.6 μM, respectively). Cytochalasin A also induces the phosphorylation of the tyrosine phosphatase PTP3 of Dictyostelium, activating STATc.

Cytochalasin A binds to the glucose transporter and inhibit monosaccharide transport across the plasma membrane. Preventing growth and sugar uptake in a Saccharomyces strain.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300+H310+H330-H361
• Precautionary statements: P201-P202-P260-P280-P302+P352+P310-P304+P340+P310
• PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
• Hazard Codes: T+,T
• Risk Statements: 26/27/28-63
• Safety Statements: 28-36/37-45
• RIDADR: UN 1544 6.1/PG 2
• WGK Germany: 3
• F: 10
• HazardClass: 6.1(a)
• PackingGroup: I
• HS Code: 29349990
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2; very toxic hazardous materials
• Hazard Classifications: Acute Tox. 1 Inhalation; Acute Tox. 2 Dermal; Acute Tox. 2 Oral; Repr. 2