S9215914
≥98%(HPLC),solid , 725247-18-7
CAS NO.：725247-18-7
Empirical Formula: C23H13F9N4O3S
Molecular Weight: 596.42
MDL number: MFCD08277031
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1939.49 | In Stock |
|
| 25mg | RMB7469.63 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| storage temp. | 2-8°C |
| solubility | DMSO: ≥10mg/mL |
| form | solid |
| color | yellow |
| InChIKey | HQFNFOOGGLSBBT-AWNIVKPZSA-N |
| SMILES | COc1cc(ccc1OCc2ccc(cc2C(F)(F)F)C(F)(F)F)\C=C(/C#N)C(=O)Nc3nnc(s3)C(F)(F)F |
Description and Uses
XCT790 is an inverse agonist of estrogen-related receptor α (ERRα; IC50 = ~300-500 nM). It demonstrates 90-100% inhibition of ERRα constitutive activity and has no significant activity at related nuclear receptors at 10 μM. XCT790 associates with the ligand-binding domain of ERRα and blocks ERRα/PGC-1α-dependent signaling, suppressing the expression of monoamine oxidases A and B. XCT790 induces proteasomal degradation of ERRα and potentiates the degradation of the estrogen receptor ERα by fulvestrant .
XCT790 is a potent inverse agonist of ERRα.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H413 |
| Precautionary statements | P264-P270-P273-P301+P312-P330 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Chronic 4 |
